Adjunct Assistant Professor Liu Shuang

 

Liu Shuang
PhD (Oxford); MSci (Imperial)
Principal Investigator, A*STAR Institute of Molecular and Cell Biology;
Adjunct Assistant Professor, Department of Anatomy, Yong Loo Lin School of Medicine, NUS
Address: 61 Biopolis Drive, Proteos, #05-17B, Singapore 138673
Tel: +65 6586 9783
Email: liu_shuang@a-star.edu.sg
Website:
https://www.a-star.edu.sg/imcb/people/shuang-liu

Major Research Interests

  • Molecular glue and proximity-inducing small-molecule discovery
  • DNA-encoded library (DEL) screening platforms for drug discovery
  • Targeted protein degradation, stabilisation, and protein–protein interaction modulation in cancer
  • Targeted protein disaggregation and signalling rewiring in neurodegenerative disease

    • Recent Publications

    1. H. Aliee, L. Bejarano-Bosque, R. Castells-Graells, D. Caswell, M. J. Friedrich, C. Gurjao, R. K. Li, S. Liu, S. Minnie, R. A. Schoot, Z. Tang. The 2025 generation. Nat. Cancer 6, 1930–1934 (2025). (Viewpoint article; authors listed alphabetically)
    2. Y. T. Chow, B. Tong, Z. T. Tan, A. Tutter, Z. Nan, P. Horton, M. Romanowski, F. Zécri, S. L. Schreiber, S. Liu*. Selectivity Profiling of Bromodomain PROTACs using Chemical Inducers of Proximity DNA-Encoded Library Screening. ACS Chem. Biol. 20 (9), 2266–2276 (2025)
    3. J. W. Mason, Y. T. Chow, L. Hudson, A. Tutter, G. Michaud, M. V. Westphal, W. Shu, X. Ma, Z. Y. Tan, C. W. Coley, P. A. Clemons, S. Bonazzi, F. Berst, K. Briner, S. Liu*, F. J. Zécri*, S. L. Schreiber*. DNA-encoded library-enabled discovery of proximity-inducing small molecules. Nat. Chem. Biol., 20, 170–179 (2024)
    4. S. Liu*, B. Tong, J. W. Mason, J. O. Ostrem, A. Tutter, B. K. Hua, S. A. Tang, S. Bonazzi, K. Briner, F. Berst, F. J. Zécri, S. L. Schreiber*. Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein Associations. J. Am. Chem. Soc. 145 (42), 23281–23291 (2023)
    5. S. Liu, M. Abboud, V. Mikhailov, X. Liu, R. Reinbold, C. J. Schofield. Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors. J. Med. Chem., 66, 5279–5288 (2023)
    6. S. Liu, M. I. Abboud, T. John, V. Mikhailov, I. Hvinden, J. Walsby-Tickle, X. Liu, I. Petinatti, T. Cadoux-Hudson, J. S. O. McCullagh, C. J. Schofield. Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1. Commun. Biol. 4, 1243 (2021)
    7. S. Liu, T. Cadoux-Hudson, C. J. Schofield. Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities. Curr. Opin. Chem. Biol. 57, 122–134 (2020)