{"id":1844,"date":"2021-02-08T05:31:34","date_gmt":"2021-02-08T05:31:34","guid":{"rendered":"https:\/\/www.lsi.nus.edu.sg\/corp\/?page_id=1844"},"modified":"2026-03-24T10:22:44","modified_gmt":"2026-03-24T02:22:44","slug":"prof-s-thameem-dheen","status":"publish","type":"page","link":"https:\/\/www.nus.edu.sg\/lsi\/principal-investigators-3\/prof-s-thameem-dheen\/","title":{"rendered":"Prof S Thameem DHEEN"},"content":{"rendered":"

\"\" S Thameem Dheen<\/strong>
\n(PhD; M Phil; MSc; BSc)
\nHead, Department of Anatomy, NUS Medicine
\nMember, LSI Neurobiology Programme
\nMember, NUS Medicine Healthy Ageing Translational Research Program
\nNational University of Singapore
\n4 Medical Drive, MD10, YLLSoM, Singapore 117594
\nTel: 6516 3217\/3200
\nEmail: antstd@nus.edu.sg<\/strong><\/a>
\nWebsite: https:\/\/nus.edu.sg\/lsi\/principal-investigators-3\/assoc-prof-s-thameem-dheen\/<\/a><\/p>\n

\nMajor Research Interests<\/strong><\/h3>\n
  • Role of microglia in memory formation and learning <\/li>\n
  • Understanding the role of microglia in cognitive processes in healthy aging brain<\/li>\n
  • Molecular and epigenetic mechanisms underlying microglia-mediated neuroinflammation and neuroprotection <\/li>\n
  • Unravelling the molecular and epigenetic landscape of maternal diabetes-induced neurodevelopmental disorders<\/li>\n

    Selected Recent Publications<\/strong><\/h3>\n

    1.Kandilya D; Shyamasundar S; Singh DK; Banik A; Hande MP; St\u00fcnkel W; Chong YS; Dheen ST (2020). High glucose alters the DNA methylation pattern of neurodevelopment associated genes in human neural progenitor cells in vitro. Scientific Reports Vol. 10 (1):15676.
    \n2. Gupta N; Jadhav S; Tan K-L; Saw G; Mallilankaraman KB; Dheen ST (2020). miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A. Frontiers In Cellular Neuroscience Vol. 14:132.
    \n3. Saw G; Krishna K; Gupta N; Soong TW; Mallilankaraman K; Sajikumar S; Dheen ST (2019). Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. GLIA Vol. 68 (3), pp. 656 \u2013 669.
    \n4. Subhramanyam CS; Wang C; Hu Q; Dheen ST (2019). Microglia-mediated neuroinflammation in neurodegenerative diseases. Seminars In Cell & Developmental Biology Vol. 94, pp. 112 \u2013 120.
    \n5. Kandilya D; Maskomani S; Shyamasundar S; Tambyah PA; Yng CS; Lee RCH; Hande MP; Mallilankaraman K; Chu JTH; Dheen ST (2019). Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells. Epigenomics Vol. 11 (10), pp. 1143 \u2013 1162.
    \n6. Karthikeyan A; Gupta N; Tang C; Mallilankaraman K; Silambarasan M; Shi M; Lu L; Ang BT; Ling EA; Dheen ST (2018). Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment. Oncotarget Vol. 9 (38) pp. 24950 \u2013 24969.
    \n7. Patnala R; Arumugam T; Gupta N; Dheen ST (2017). HDAC Inhibitor Sodium Butyrate-Mediated Epigenetic Regulation Enhances Neuroprotective Function of Microglia During Ischemic Stroke. Molecular Neurobiology Vol. 54 (8), pp. 6391 \u2013 6411.<\/p>\n","protected":false},"excerpt":{"rendered":"

    S Thameem Dheen (PhD; M Phil; MSc; BSc) Head, Department of Anatomy, NUS Medicine Member, LSI Neurobiology Programme Member, NUS Medicine Healthy Ageing Translational Research Program National University of Singapore 4 Medical Drive, MD10, YLLSoM, Singapore 117594 Tel: 6516 3217\/3200 Email: antstd@nus.edu.sg Website: https:\/\/nus.edu.sg\/lsi\/principal-investigators-3\/assoc-prof-s-thameem-dheen\/ Major Research Interests Role of microglia in memory formation and learningRead More<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":603,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"custompagewithmenu.php","meta":{"footnotes":""},"tags":[59],"class_list":["post-1844","page","type-page","status-publish","hentry","tag-mm-pi-neuro"],"_links":{"self":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1844"}],"collection":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/comments?post=1844"}],"version-history":[{"count":5,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1844\/revisions"}],"predecessor-version":[{"id":2500,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1844\/revisions\/2500"}],"up":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/603"}],"wp:attachment":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/media?parent=1844"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/tags?post=1844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}