{"id":1770,"date":"2020-02-27T07:37:36","date_gmt":"2020-02-27T07:37:36","guid":{"rendered":"https:\/\/www.lsi.nus.edu.sg\/corp\/?page_id=1770"},"modified":"2023-02-17T08:50:31","modified_gmt":"2023-02-17T08:50:31","slug":"dr-jai-santosh-polepalli","status":"publish","type":"page","link":"https:\/\/www.nus.edu.sg\/lsi\/principal-investigators-3\/dr-jai-santosh-polepalli\/","title":{"rendered":"Dr Jai Santosh Polepalli"},"content":{"rendered":"

\"\" Jai Santosh Polepalli<\/strong>
\nAssistant Professor, Department of Anatomy Yong Loo Lin School of Medicine, NUS
\nPrincipal Investigator, LSI Neurobiology Programme,
\nNational University of Singapore
\nCentre for Life Sciences, 28 Medical Drive #05-01L
\nSingapore 117456
\nTel: 6516 3201
\nEmail: jpolepalli@nus.edu.sg
\n<\/strong><\/a>
\nWebsite: www.polepallilab.org<\/a><\/p>\n

\nMajor Research Interests<\/strong><\/h3>\n

My group studies the core mechanisms of neuronal synaptic and circuit function, including activity-dependent changes in synaptic strength and circuit connectivity in key regions of the brain that mediate memory-guided and reward-seeking behaviours.<\/p>\n

Our research scope spans from molecular & cell biology to systems neuroscience. Our goal is to probe the molecular, synaptic and neuronal circuit malfunctions that are often found in disease. We are particularly interested in the functional characterisation of mutations which are commonly found in patients with neuropsychiatric disorders like autism spectrum disorders and schizophrenia. <\/p>\n

Current Projects<\/strong><\/h3>\n
  • Molecular coding of synapses in the hippocampus<\/li>\n
  • Molecular circuitry of reward-seeking<\/li>\n
  • Ageing-related human neuronal activity changes<\/li>\n

    Selected Recent Publications<\/strong><\/h3>\n

    1.\tLiakath-Ali K*, Polepalli JS*^, Lee SJ, Cloutier JF, Sudhof TC^. Trans-synaptic Cerebellin4 – neogenin1 signalling mediates LTP in the mouse dentate gyrus. PNAS 2022; 119(20) (corresponding author)
    \n2.\tPolepalli JS, Gooch H, Sah P. Diversity of interneurons in the lateral and basal amygdala. njp Science of Learning 2020
    \n3.\tSeigneur E, Polepalli JS, Sudhof TC. Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs. Proceedings of the National Academy of Sciences. 2018; 201811086
    \n4.\tHung LW, Neuner S*, Polepalli JS*, Beier KT*, Wright M, Walsh JJ, Eastman LM, Luo L, Deisseroth K, Dolen G, Malenka R. Gating of social reward by oxytocin in the ventral tegmental area. Science. 2017; 357 (6358): 1406-1411
    \n5.\tPolepalli JS, Wu H, Goswami D, Halpern CH, Sudhof TC and Malenka RC. Modulation of excitation on parvalbumin interneurons by neuroligin-3 regulates the hippocampal network. Nature Neuroscience. 2017; 20(2):219-229
    \n6.\tPolepalli JS*, Jiang M*, Chen LY, Zhang B, Sudhof TC and Malenka RC. Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell autonomous NMDA receptor independent mechanism. Molecular Psychiatry. 2017; 22(3):375-383 (* co-first author)
    \n7.\tSchwartz N, Temkin P, Jurado S, Lim BK, Heifets BD, Polepalli JS and Malenka RC. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens. Science. 2014; 345(6196):535-42
    \n8.\tPolepalli JS*, Ahmad M*, Goswami D, Yang X, Kaesar-Woo Y, S\u00fcdhof TC and Malenka RC. Postsynaptic Complexin Controls AMPA Receptor Exocytosis During LTP. Neuron. 2012; 73(2):260-7 (* co-first author)<\/p>\n","protected":false},"excerpt":{"rendered":"

    Jai Santosh Polepalli Assistant Professor, Department of Anatomy Yong Loo Lin School of Medicine, NUS Principal Investigator, LSI Neurobiology Programme, National University of Singapore Centre for Life Sciences, 28 Medical Drive #05-01L Singapore 117456 Tel: 6516 3201 Email: jpolepalli@nus.edu.sg Website: www.polepallilab.org Major Research Interests My group studies the core mechanisms of neuronal synaptic and circuitRead More<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":603,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"custompagewithmenu.php","meta":{"footnotes":""},"tags":[59],"class_list":["post-1770","page","type-page","status-publish","hentry","tag-mm-pi-neuro"],"_links":{"self":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1770"}],"collection":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/comments?post=1770"}],"version-history":[{"count":8,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1770\/revisions"}],"predecessor-version":[{"id":2171,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1770\/revisions\/2171"}],"up":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/603"}],"wp:attachment":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/media?parent=1770"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/tags?post=1770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}