{"id":1488,"date":"2019-07-04T01:53:19","date_gmt":"2019-07-04T01:53:19","guid":{"rendered":"https:\/\/www.lsi.nus.edu.sg\/corp\/?page_id=1488"},"modified":"2023-02-17T09:11:42","modified_gmt":"2023-02-17T09:11:42","slug":"prof-soong-tuck-wah","status":"publish","type":"page","link":"https:\/\/www.nus.edu.sg\/lsi\/principal-investigators-3\/prof-soong-tuck-wah\/","title":{"rendered":"Prof Soong Tuck Wah"},"content":{"rendered":"

\"\"Soong Tuck Wah<\/strong>
\nPh.D
\nProfessor, Department of Physiology
\nSenior Faculty, NUS Graduate School \u2013 Integrative and Engineering Programme
\nS9 Wet Science Building, Level 11
\nNational University of Singapore
\n4 Science Drive 2, S9-11-02A Singapore 117544
\nTel : (65) 6516 1938
\nEmail: phsstw@nus.edu.sg<\/strong><\/a>
\nWebsite: http:\/\/medicine.nus.edu.sg\/phys\/lab\/Soong_Lab\/Home.html<\/a>
\nhttps:\/\/nus.edu.sg\/lsi\/principal-investigators-3\/prof-soong-tuck-wah\/<\/a><\/p>\n

\nMajor Research Interests<\/strong><\/h3>\n
  • Investigations into diversification of calcium channel function via alternative splicing and RNA editing and their implications in neurological disorders such as anxiety or fear and in cardiovascular disorders such as hypertension and heart failure. <\/li>\n
  • Investigations into physiological significance of alternative splicing and RNA editing of CaV channels in hippocampal learning and memory and cerebellar motor learning, and in feeding behavior and circadian rhythm.<\/li>\n
  • Determination of the role of iron and manganese in Parkinson\u2019s disease and in neurotoxicity. <\/li>\n

    Recent Publications<\/strong><\/h3>\n

    1.\tH Huang, BZ Tan, Y Shen, J Tao, F Jiang, YY Sung, CK Ng, M Raida, G, K\u00f6hr, M Higuchi H Fatemi-Shariatpanahi, DT Yue and TW Soong. RNA editing of the IQ domain in Cav1.3 channels modulates their Ca2+-dependent inactivation. Neuron, 2012 Jan 26;73(2):304-16
    \n2.\tPapanayotou C, Almeida ID, Liao P, Oliveira NA, Lu SQ, Kougioumtzidou, E, Zhu L, Shaw A, Sheng G, Streit A, Yu D, Soong TW and Stern CD Calfacilitin: a novel calcium channel modulator essential for initiation of neural plate development Nature Commun, 4, 1837, 14 May 2013
    \n3.\tBazzazi H, Johny MB, Adams PJ, Soong TW and Yue DT Continuosly tunable Ca2+ regulation of RNA-edited CaV1.3 channels Cell Reports, 2013, Oct 31; 5:1-11. doi:10.1016\/j.cell.rep2013.09.006
    \n4.\tHuang H, Ng CY, Yu D, Zhai J, Lam Y and Soong TW. Modest CaV1.342-selective inhibition by compound 8 is a subunit dependent Nature Commun, 2014, Jul 24; 5:4481 (Faculty 1000\/ Prime).
    \n5.\tLi G, Wang J, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F, Yong TF, Wong YP, Hu ZY, Huang H, Zhang G, Galupo MJ, Bian JS, Ponniah S, Trasti SL, See K, Foo R, Hoppe UC, Herzig S and Soong TW. Exclusion of alternative exon 33 of CaV1.2 channels in heart is pro arrhythmogenic. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4288-E4295.
    \n6.\tHu Z, Li G, Wang JW, Chong SY, Yu D, Wang X, Soon JL, Liang MC, Wong, YP, Huang N, Colecraft HM, Liao P, Soong TW
    \nRegulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction. Circulation. 2018, Oct 2;138(14):1431-1445.
    \n7.\tHuang H, Kapeli K, Jin W, Wong YP, Arumugam TV, Koh JH, Srimasorn S, Mallilankaraman K, Chua JJE, Yeo GW and Soong TW. Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9. Nucleic Acids Res. 2018 Aug 21;46(14):7323-7338.
    \n8.\tLiu C, Zhang CW, Lo SQ, Ang ST, Chew KCM, Yu D, Chai BH, Tan B, Tsang F, Tai YK, Tan BWQ, Liang MC, Tan HT, Tang JY, Lai MKP, Chua JJE, Chung MCM, Khanna S, Lim KL, Soong TW. S-nitrosylation of divalent metal transporter 1 enhances iron uptake to mediate loss of dopaminergic neurons and motoric deficit. J Neurosci. 2018 Sep 26;38(39):8364-8377.
    \n9.\tTan S, Xia Y, Yin HH, Chen AI, Soong TW, and Je HS. Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9909-E9915.
    \n10.\tMei Q, Bansal A, Jayakumar MKG, Zhang Z, Zhang J, Huang H, Yu D, Ramachandra CJA, Hausenloy DJ, Soong TW, Zhang Y.
    \nManipulating energy migration within single lanthanide activator for Switchable upconversion emissions towards bidirectional photoactivation. Nat Commun. 2019 Sep 27;10(1):4416.
    \n11.\tHuang H, Tay SH, Ng W, Ng SY, Soong TW.
    \nTargeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides. Pain, 2021, Jul 1;162(7):2097-2109. doi:10.1097\/j.pain.0000000000002216
    \n12.\tNavakkode S, Zhai J, Wong YP, Li G, Soong TW. Enhanced long-term potentiation and impaired learning in mice lacking alternative exon 33 of Cav1.2 calcium channel. Transl Psychiatry. 2022 Jan 10;12(1):1.
    \n13.\tZhang Z, Dalan R, Hu Z, Wang JW, Chew NW, Poh KK, Tan RS, Soong TW, Dai Y, Ye L, Chen X
    \nReactive oxygen species scavenging nanomedicine for the treatment of ischemic heart disease. Adv Mater. 2022 Apr 25:e2202169.
    \n14.\tZhai J, Navakkode S, Yeow SQZ, Krishna-K K, Liang MC, Koh JH, Wong RX, Yu WP, Sajikumar S, Huang H, Soong TW
    \nLoss of Ca V 1.3 RNA editing enhances mouse hippocampal plasticity,vlearning, and memory. Proc Natl Acad Sci U S A. 2022
    \nAug 9; 119(32):e2203883119. doi: 10.1073\/pnas.2203883119.
    \n15.\tHu Z, Zhang B, Lim LJY, Loh, WZK, Yu D, Tan BWQ, Liang MC, Huang Z, Leo CH, Huang H and Soong TW.
    \nS-nitrosylation-mediated reduction of Cav1.2 surface expression and open probability underlies attenuated vasoconstriction induced by nitric oxide. Hypertension, 2022 Dec;79(12):2854-2866. doi:10.1161\/HYPERTENSIONAHA.122.19103.<\/p>\n","protected":false},"excerpt":{"rendered":"

    Soong Tuck Wah Ph.D Professor, Department of Physiology Senior Faculty, NUS Graduate School \u2013 Integrative and Engineering Programme S9 Wet Science Building, Level 11 National University of Singapore 4 Science Drive 2, S9-11-02A Singapore 117544 Tel : (65) 6516 1938 Email: phsstw@nus.edu.sg Website: http:\/\/medicine.nus.edu.sg\/phys\/lab\/Soong_Lab\/Home.html https:\/\/nus.edu.sg\/lsi\/principal-investigators-3\/prof-soong-tuck-wah\/ Major Research Interests Investigations into diversification of calcium channel functionRead More<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":603,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"custompagewithmenu.php","meta":{"footnotes":""},"tags":[59],"class_list":["post-1488","page","type-page","status-publish","hentry","tag-mm-pi-neuro"],"_links":{"self":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1488"}],"collection":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/comments?post=1488"}],"version-history":[{"count":8,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1488\/revisions"}],"predecessor-version":[{"id":2190,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1488\/revisions\/2190"}],"up":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/603"}],"wp:attachment":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/media?parent=1488"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/tags?post=1488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}