{"id":1376,"date":"2019-06-17T03:39:10","date_gmt":"2019-06-17T03:39:10","guid":{"rendered":"https:\/\/www.lsi.nus.edu.sg\/corp\/?page_id=1376"},"modified":"2024-06-21T08:21:55","modified_gmt":"2024-06-21T08:21:55","slug":"prof-lee-eng-hin","status":"publish","type":"page","link":"https:\/\/www.nus.edu.sg\/lsi\/tissue-engineering\/principal-investigators\/prof-lee-eng-hin\/","title":{"rendered":"Prof Lee Eng Hin"},"content":{"rendered":"

\"\"Lee Eng Hin<\/strong>
\nEmeritus Professor, Department of Orthopaedic Surgery,
\nYong Loo Lin School of Medicine
\nEmeritus Consultant, Department of Orthopaedic Surgery, National University Hospital, Singapore
\nTel: 6772 4321
\nEmail: dosleeeh@nus.edu.sg<\/strong><\/a><\/p>\n

\nWhat are your present research interests?<\/strong><\/h3>\n

My main interest is in the repair and regeneration of articular and physeal cartilage. The thrust in our lab is to find ways to optimise chondrogenesis by manipulation of the biochemical, physical, electrical and mechanical micro-microenvironmental cues of chondrocytes and stem cells. The eventual aim is to improve upon the current clinical outcomes of cartilage repair.<\/p>\n

\nDo you have a distinctive viewpoint to your research?<\/strong><\/h3>\n

Cartilage is a very complex tissue that does not heal when injured. The challenge in cartilage repair is to be able to recapitulate the zonal architecture in the cartilage tissue that has the same phenotype and function as normal cartilage and is able to withstand the mechanical demands of constant motion and weight bearing.<\/p>\n

What do you see as your future research directions?<\/strong><\/h3>\n

Our efforts will be directed at finding novel ways to repair and regenerate articular and physeal cartilage that will restore the function of the joint and enable normal growth in long bones in children.<\/p>\n


\nDoes your laboratory have a particularly strong research expertise?<\/strong><\/h3>\n

Our key strength is in the multi-disciplinary nature of our research teams with the expertise to translate our findings from the benchtop to the bedside.<\/p>\n


\nRecent Publications<\/strong><\/h3>\n

1. Teo AQN, Wong KL, Shen L, Lim JY, Toh WS, Lee EH, Hui JHP.
\nEquivalent 10-Year Outcomes After Implantation of Autologous Bone Marrow-Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation for Chondral Defects of the Knee.
\nAmerican Journal of Sports Medicine, (2019, October); 47(12): 2881-2887.
\nhttps:\/\/journals.sagepub.com\/doi\/10.1177\/0363546519867933<\/a><\/p>\n

2. Lu Y, Yang Z, Wu Y, Denslin V, Yu CC, Tee CA, Lim CT, Han J, Lee EH.
\nLabel-free separation of mesenchymal stem cell subpopulations with distinct
\ndifferentiation potencies and paracrine effects.
\nBiomaterials (2020, February); 240:119881.
\nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2020.119881<\/a><\/p>\n

3. Wu Y, Yang Z, Denslin V, Ren X, Lee CS, Yap FL, Lee EH
\nRepair of Osteochondral Defects With Predifferentiated Mesenchymal Stem Cells of Distinct Phenotypic Character Derived From a Nanotopographic Platform
\nAmerican Journal of Sports Medicine (2020, Jun); 48(7):1735-1747.
\nhttps:\/\/doi.org\/10.1177\/0363546520907137<\/a><\/p>\n

4. Wong KL, Zhang S, Wang M, Ren FS, Afizah H, Lai RC, Lim SK, Lee EH, Hui JHP, Toh WS.
\nIntra-Articular Injections of Mesenchymal Stem Cell Exosomes and Hyaluronic Acid Improve Structural and Mechanical Properties of Repaired Cartilage in a Rabbit Model.
\nArthroscopy (2020 August); 36 (8): 2215-2228.e2;
\nhttps:\/\/doi.org\/10.1016\/j.arthro.2020.03.031<\/a><\/p>\n

5. Kadir ND, Yang Z, Hassan A, Denslin V, Lee EH.
\nElectrospun fibers enhanced the paracrine signaling of mesenchymal stem cells for cartilage regeneration.
\nStem Cell Res & Ther. (2021 Feb); 12(1):100. <\/p>\n

6. Yang YM, Lee EH, Yang Z.
\nHypoxia conditioned mesenchymal stem cells in tissue regeneration application.
\nTissue Eng Part B Rev. 2022, 28 (5): 966-977.
\nhttps:\/\/www.liebertpub.com\/doi\/10.1089\/ten.teb.2021.0145<\/a><\/p>\n

7. Tee CA, Yang Z, Wu YN, Ren XF, Baranski M, Lin DJ, Hassan A, Han J, Lee EH.
\nA Pre-Clinical Animal Study for Zonal Articular Cartilage Regeneration Using
\nStratified Implantation of Microcarrier Expanded Zonal Chondrocytes.
\nCARTILAGE April-June 2022: 1\u201316, 2022.
\nhttps:\/\/journals.sagepub.com\/doi\/10.1177\/19476035221093063<\/a><\/p>\n

8. Yang Z, Celik C, Parate D, Franco-Obreg\u00f3n A, Lee EH (2022).
\nThe application of pulsed electromagnetic field for cartilage regeneration.
\nTissue Eng Part A 28, S-365.<\/p>\n

9. Yang YM, Wu Y, Neo SH, Kadir ND, Goh D, Tan JX, Denslin V, Lee EH, Yang Z.
\nSecretive derived from hypoxia preconditioned mesenchymal stem cells promote cartilage regeneration and mitigate joint inflammation via extracellular vesicles.
\nBioactive Materials, 2023, 27: 98-112.
\nhttps:\/\/doi.org\/10.1016\/j.bioactmat.2023.03.017<\/a><\/p>\n

10. Yang Z, Wu Y, Neo SH, Yang D, Jeon H, Tee CA, Denslin V, Lin DJ, Lee EH, Boyer LA, Han J.
\nSize-Based Microfluidic-Enriched Mesenchymal Stem Cell Subpopulations Enhance Articular Cartilage Repair.
\nAm Journal of Sports Med. 2024;52(2):503\u2013515.
\nhttps:\/\/doi.org\/10.1177\/03635465231214431<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Lee Eng Hin Emeritus Professor, Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine Emeritus Consultant, Department of Orthopaedic Surgery, National University Hospital, Singapore Tel: 6772 4321 Email: dosleeeh@nus.edu.sg What are your present research interests? My main interest is in the repair and regeneration of articular and physeal cartilage. The thrust in our labRead More<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":637,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"custompagewithmenu.php","meta":{"footnotes":""},"tags":[52],"class_list":["post-1376","page","type-page","status-publish","hentry","tag-mm-pi-tep"],"_links":{"self":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1376"}],"collection":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/comments?post=1376"}],"version-history":[{"count":10,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1376\/revisions"}],"predecessor-version":[{"id":2313,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/1376\/revisions\/2313"}],"up":[{"embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/pages\/637"}],"wp:attachment":[{"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/media?parent=1376"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nus.edu.sg\/lsi\/wp-json\/wp\/v2\/tags?post=1376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}