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1. Introduction

All staff undertaking lab-based research projects are required to conduct a project risk assessment to identify the safety and health risks associated with the project. PIs are required to complete a project risk assessment (PRA) form, which would then be forwarded to OSHE for review and final approval by Institutional Laboratory Safety Committee (ILSC) or Institutional Biosafety Committee (IBC). IBC approves life science related research projects and ILSC approves non-life science related projects.

2. Submission of PRA

With effect from 17 December 2007, all submissions of PRAs must be done online through the Online Project Risk Assessment System (OPRAS)

Details on how to use Online Project Risk Assessment System (OPRAS) can be found here.

3. Key Considerations when doing PRA can be found here.

4. Revisions to PRA

In the course of conducting research projects in NUS, if there are significant changes in the protocol, practices, material, personnel or environment that would require additional risk controls, PIs should submit Project Risk Assessment (Revision form) to OSHE for review and approval.

To download Project Risk Assessment (Revision Form)

5. For PIs awarded certification to the Laboratory OHS certification scheme

Upon award of the certification, PIs need not submit individual project risk assessments for new grant-based projects.  However, PIs must notify OSHE of new projects and submit the following form(s) to OSHE to apply for approval for the release of funds for the new projects:

  • Form (OSH/PI/F02.02) – Grant release form for Laboratory OSH Certification Scheme


  • Form (OSH/PI/F03.02) – This form is to be submitted in addition to the form (OSH/PI/F02.02) if the new project involves animal work.

    6. Conducting sponsored field research, including projects potentially involving animals?

    Many research projects involve off campus field activities which may present personnel with unique hazards not necessarily encountered when conducting laboratory based research, including exposure to wild animals.

    In lieu of the laboratory-based risk assessment, this form must be completed for project risk assessments involving sponsored field research in order to address the safety considerations and emergency response preparations necessary during field research activities.

    For general enquiries, please contact Sania at ext. 1084 (

     Online Project Risk Assessment System (OPRAS)


    For login from outside NUS, you need to login to NUS WEB VPN ( in order to gain access to OPRAS.

    2. Approval Process

    3. OPRAS Resources

    Roadshow On 21 November 2007:

    Training Manuals:


    Comments & Feedbacks:

    Request For Access by Departmental Administrators:

     Key Considerations when doing PRA

    3.1 PRA involving biological work

    Flowchart of action required for risk assessments

    Flowchart to determine biosafety levels

    3.2 PRAs involving “BATA agents”

    All Principal Investigators (PIs) performing genetic manipulation work or work involving agents regulated under the Biological Agents & Toxins Act (BATA) should provide documentation of the information as requested for in the following checklist. Risk Assessment/Checklist-nus-risk-assessment.htm

    3.3  Useful References




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