NUS Graduate School for Integrative Sciences and Engineering

Valedictorians

 

Class of
Valedictorian / Thesis Title
Publications
2017

TAN Mei Hui, PhD

Thesis Title: Analysis of Retinal Images for Glaucoma Diagnosis

  1. Mei Hui Tan, Ying Sun, Sim Heng Ong, Jiang Liu, Mani Baskaran, Tin Aung, & Tien Yin Wong. (2013, April). Automatic notch detection in retinal images. In Biomedical Imaging (ISBI), 2013 IEEE 10th International Symposium on (pp. 1440-1443). IEEE.
  2. Mei Hui Tan, Sim Heng Ong., Sri Gowtham Thakku, Cheng, Ching Yu, Tin Aung., & Michael Girard. (2015, June). Automatic Feature Extraction of Optical Coherence Tomography for Lamina Cribrosa Detection. In 2015 4th International Conference on Computing and Computer Vision (ICCCV).

Also award Best Oral Presentation

2016

ER Jun Cheng, PhD

Thesis Title: The Evolution of Fluorescent Probe Development

  1. Zhang, L.;† Er, J. C.;† Jiang, H.; Li, X.; Luo, Z.; Yi, F.; Thomas, R.; Tang, M. K.; Chang, Y.-T.; Vendrell, M., A Highly Selective Fluorogenic Probe for Cu/Zn Superoxide Dismutase. Chem. Commun. 2016, 52, 9093-9096. († Co-first authorship)
  2. Wang, L.; Yuan, L.; Zeng, X.; Peng, J.; Er, J. C.; Xu, W.; Agrawalla, B. K.; Su, D.; Chang, Y.-T., A Multisite-Binding Switchable Fluorescent Probe for Monitoring Mitochondrial ATP Level Fluctuation in Live Cells. Angew. Chem., Int. Ed. 2016, 55 (5), 1773-1776.
  3. Teoh, C. L.; Er, J. C.; Mukherjee, P.; Chang, Y.-T., NeuO for Neuronal Labelling in Zebrafish. Tomography 2015, 1 (1), 30-36.
  4. Er, J. C.;† Leong, C.;† Teoh, C. L.; Yun, S.-W.; Chang, Y.-T.; et al., NeuO: a Fluorescent Chemical Probe for Live Neuron Labeling. Angew. Chem., Int. Ed. 2015, 54 (8), 2442-2446. († Co-first authorship) (Highlighted in Straits Times, Aug. 17, 2015 and Aug. 21, 2015) (IF: 11.261)
  5. Zhang, L.; Er, J. C.; Li, X.; Heng, J. J.; Samanta, A.; Chang, Y.-T.; Lee, C.-L. K., Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach. Chem. Commun. 2015, 51 (34), 7386-7389. († Co-first authorship) (IF: 6.834)
  6. Peng, J.; Xu, W.; Teoh, C. L.; Han, S.; Kim, B.; Samanta, A.; Er, J. C.; Wang, L.; Yuan, L.; Liu, X.; Chang, Y.-T., High-Efficiency in Vitro and in Vivo Detection of Zn2+ by Dye-Assembled Upconversion Nanoparticles. J. Am. Chem. Soc. 2015, 137 (6), 2336-2342. (IF: 12.113)
  7. Zhang, L.; Er, J. C.; Xu, W.; Qin, X.; Samanta, A.; Jana, S.; Lee, C.-L. K.; Chang, Y.-T., “Orange alert”: A fluorescent detector for bisphenol A in water environments. Anal. Chim. Acta 2014, 815 (0), 51-56.
  8. Zhang, L.;† Er, J. C.; † Ghosh, K. K.; Chung, W. J.; Yoo, J.; Xu, W.; Zhao, W.; Phan, A. T.; Chang, Y.-T., Discovery of a Structural-Element Specific G-Quadruplex “Light-Up” Probe. Sci. Rep. 2014, 4, 3776. († Co-first authorship)
  9. Er, J. C.; Vendrell, M.; Tang, M. K.; Zhai, D.; Chang, Y.-T., Fluorescent Dye Cocktail for Multiplex Drug-Site Mapping on Human Serum Albumin. ACS Comb. Sci. 2013, 15 (9), 452-457. (Cover Page in ACS Comb. Sci. 2013, September issue)
  10. Er, J. C.; Tang, M. K.; Chia, C. G.; Liew, H.; Vendrell, M.; Chang, Y.-T., MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes. Chem. Sci. 2013, 4 (5), 2168-2176. (IF: 9.211)
  11. Xu, W.; Kim, T.-H.; Zhai, D.; Er, J. C.; Zhang, L.; Kale, A. A.; Agrawalla, B. K.; Cho, Y.-K.; Chang, Y.-T., Make caffeine visible: a fluorescent caffeine “Traffic Light” detector. Sci. Rep. 2013, 3, 2255. (Highlighted in ABC News, Aug. 8, 2013 and Real Clear Science, Aug 4, 2013)
  12. Vendrell, M.; Zhai, D.; Er, J. C.; Chang, Y.-T., Combinatorial strategies in fluorescent probe development. Chem. Rev. 2012, 112 (8), 4391-4420. (IF: 46.568)

Patents

MegaStokes Amino-Triazolyl-BODIPYs Compounds and Application To Live Neuron Staining and Human Serum Albumin FA1 Drug Site Probing, Chang, Y. T.; Er, J. C.; Leong, C. K. M.; Yun, S. W.; Vendrell, M. E.; Tang, M.K.; US Provisional Appl. 61/745916 (2012 Dec 26) PCT Int. Appl. PCT/SG2013/000550 (2013 Dec 26).

2015

CHUA En Lin Christelle, PhD

Thesis Title: Investigations on Rab31's Role in EGFR Trafficking and Neural Progenitor Cell Differentiation Towards Astroglia

Research papers

  1. Chua C, Yim A, Tang B. 2015. Approaches to analyse the role of Rab GTPases in endocytic trafficking of Epidermal Growth Factor Receptor (EGFR). Methods Mol Biol. 1270:239-251.
  2. Chua C, Tang B. 2014. Engagement of small GTPase Rab31 protein and its effector, Early Endosome Antigen 1, is important for the trafficking of ligand-bound Epidermal Growth Factor Receptor from early endosome to late endosome. J Biol Chem. 289:12375-12389
  3. Chua C, Goh E, Tang B. 2014. Rab31 is expressed in Neural Progenitor Cells and plays a role in their differentiation. FEBS Lett. 588:3186-3194
  4. Chua C, and Tang B. 2008. Syntaxin 16 is enriched in neuronal dendrites and may have a role in neurite outgrowth.  Mol Membr Biol. 25:35-45.

Review Papers

  1. Chua C, Tang B. 2015. Role of Rab GTPases and their interacting proteins in mediating metabolic signalling and regulation. Cell Mol Life Sci. 72:2289-2304.
  2. Chua C, Tang B. 2015. The role of the small GTPase Rab31 in cancer. J Cell Mol Med. 19:1-10.
  3. Chua C, Chan S, Tang B. 2014. Non-cell autonomous or secretory tumour suppression. J Cell Physiol. 229:1346-1352.
  4. Chua C, and Tang B. 2013. Linking membrane dynamics and trafficking to autophagy and the unfolded protein response.  J Cell Physiol. 228:1638-1640.
  5. Chua C, Lim Y, Lee M, and Tang B. 2012. Non-classical membrane trafficking processes galore.  J Cell Physiol. 227:3722-3730.
  6. Chua C, Gan B, and Tang B. 2011. Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation.  Cell Mol Life Sci. 68:3349-3358.
  7. Lim Y, Chua C, and Tang B. 2011. Rabs and other small GTPases in ciliary transport.  Biol Cell. 103:209-221.
  8. Chua C, and Tang B. 2011. Rabs, SNAREs and α-synuclein--membrane trafficking defects in synucleinopathies.  Brain Res Rev. 67:268-281.
  9. Tang B, and Chua C. 2010. Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders?  Biochem Biophys Res Commun. 391:6-10.
  10. Chua C, Lim Y, and Tang B. 2010. Rab35--a vesicular traffic-regulating small GTPase with actin modulating roles.  FEBS Lett. 584:1-6.
  11. Tang B, and Chua C. 2008. SIRT1 and neuronal diseases.  Mol Aspects Med. 29:187-200.
  12. Tang B, and Chua C. 2008. SIRT2, tubulin deacetylation, and oligodendroglia differentiation.  Cell Motil Cytoskeleton. 65:179-182.
  13. Chua C, and Tang B. 2006. alpha-synuclein and Parkinson's disease: the first roadblock.  J Cell Mol Med. 10:837-846.
2014

YIM Guo Rong Daniel, PhD

Thesis Title: The Regulation of Sprouty by Casein Kinase 1

Publications

  1. Kaiwen Ivy Liu, Muhammad Nadzim Bin Ramli, Cheok Wei Ariel Woo, Yuanming Wang, Tianyun Zhao, Xiujun Zhang, Guo Rong Daniel Yim, Bao Yi Chong, Ali Gowher, Mervyn Zi Hao Chua, Jonathan Jung, Jia Hui Jane Lee, Meng How Tan (2016). A chemical-inducible CRISPR-Cas9 system for rapid control of genome editing. Nature Chemical Biology A.O.P. 12 September 2016, doi:10.1038/nchembio.2179
  2. Jia-Chi Yeo, Jianming Jiang, Zi-Ying Tan, Guo-Rong Yim, Jia-Hui Ng, Jonathan Göke, Petra Kraus, Hong-Qing Liang, Kevin Andrew Uy Gonzales, Han-Chung Chong, Cheng-Peow Tan, Yee-Siang Lim, Nguan-Soon Tan, Thomas Lufkin and Huck-Hui Ng (2014). Klf2 is an essential factor that sustains ground state pluripotency. Cell Stem Cell 14(6), 864–872 (PMID: 24905170)
  3. Daniel GR Yim, Sujoy Ghosh, Graeme R Guy and David M Virshup (2014). Casein Kinase 1 regulates Sprouty2 in FGF-ERK signaling. Oncogene Jan 22;34(4):474-84. doi: 10.1038/onc.2013.564. Epub 2014 Jan 27. (PMID: 24469046)
  4. Daniel GR Yim and David M Virshup (2013). Unwinding the Wnt action of Casein Kinase 1. Cell Research 23(6), 737-8. Epub 2013 Apr 9 (PMID: 23567556)
  5. Yim Guo Rong Daniel (2012). Ethical Theory for "Dual-Use" Dilemmas in Synthetic Biology. Asian Bioethics Review 4.2: 150-159
  6. Manjeet Mukherjee, Soah Yee Chow, Permeen Yusoff, J Seetharaman, Cherlyn Ng, Saravanan Sinniah, Xiao Woon Koh, Nur Farehan M Asgar, Dan Li, Daniel Yim, Rebecca A Jackson, Jingxi Yew, Jingru Qian, Audrey Iyu, Yoon Pin Lim, Xingding Zhou, Siu Kwan Sze, Graeme R Guy and J Sivaraman (2012). Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. The EMBO Journal 31, 1308 - 1319 (PMID: 22252131)
  7. G.R. Yim, D.R. Ding, C.P. Wang, W.H. Leong and Y. Hong (2009). Microsatellite Markers to Complement Distinctness, Uniformity, Stability Testing of Brassica chinensis (Xiao Baicai) Varieties. The Open Horticulture Journal 2: 54-61 (ISSN: 1874-8406)
2013

Rafi Rashid, PhD

Thesis Title: The Biophysical Properties of Macromolecular Crowders and their Uptake, Distribution and Fate in Cells

Publications (peer-reviewed)

  1. Rashid R, Cazenave-Gassiot A, Gao IH, Nair ZJ, Kumar JK, Gao L, Kline KA, Wenk MR. Comprehensive analysis of phospholipids and glycolipids in the opportunistic pathogen Enterococcus faecalis. PLoS One, 12(4): e0175886 (2017).
  2. Rashid R, Veleba M, Kline KA. Focal targeting of the bacterial envelope by antimicrobial peptides. Front Cell Dev Bio, 4:55 (2016). Invited review.
  3. Rashid R, Chee SM, Raghunath M, Wohland T. Macromolecular crowding gives rise to microviscosity, anomalous diffusion & accelerated actin polymerization. Physical Biology, 12(3): 034001 (2015).
  4. Rashid R, Beyer S, Blocki A, Le Visage C, Trau D, Wohland, T, Ragunath M. Carbohydrate polymers routed to mitochondria after pinocytotic uptake: avenues for drug delivery. Biomacromolecules, 15(6): 2119-27 (2014).
  5. Rashid R, Lim NS, Chee SM, Png, SN, Wohland T, Raghunath M. Novel use for polyvinylpyrrolidone (PVP) as a macromolecular crowder for enhanced ECM deposition and cell proliferation. Journal of Tissue Engineering C, 20 (12): 994-1002 (2014).

Publications (non-peer-reviewed)

  1. Rashid R, Raghunath M, Wohland T. Macromolecular crowding and stem cell differentiation, Microscopy and Analysis, 92:23 (2012).
  2. Rashid R. Making the case for crowding. Asia Pacific Biotech News, 15(4): 30-32 (2011).
  3. Rashid R. Sharpening our focus: The microscope. Asia Pacific Biotech News, 15(2): 14-16 (2011).

Patents

Process and Materials for Medical Applications. Inventors: Raghunath M, Beyer S, Rashid R, Blocki AM, Trau D, Wohland T (2013).

2012

LAI Chow Yin, PhD

Thesis Title: Identification and Control of Nonlinear Systems using Multiple Models

Patent

  1. 2014: W. K. Teo, P. Y. Tao, C. Y. Lai, T. M. Lim, and S. Subbiah, “A Deterministic Model-Based Material Removal Method for Fan Blade Leading Edge Re-Profiling”, submitted for United States and European Union patent application.

Book Chapter

  1. C. Y. Lai and Y. C. Sun (2014). Robotic Finishing. In  A. Y. C. Nee (Ed.), Handbook of Manufacturing Engineering and Technology, Volume Robotics and Automation, Springer, November 2014.

Journals

  1. C. Y. Lai, C. Xiang, and T. H. Lee, “Data-based Identification and Control of Nonlinear Systems via Piecewise Affine Approximation,” IEEE Trans. Neural Networks, Vo. 22, No. 12, 2011, pp. 2189-2200.
  2. C. Y. Lai, C. Xiang, and T. H. Lee, “Input-output Transition Models for Discrete-time Switched Linear and Nonlinear Systems,” Control and Intelligent Systems, Vol.39, No. 1, 2011, pp. 47-59.
  3. C. Y. Lai, F. L. Lewis, V. Venkataramanan, X. Ren, S. S. Ge and T. Liew, “Disturbance and Friction Compensation in Hard Disk Drives using Neural Networks,” IEEE Trans. Industrial Electronics, Vol. 57, No. 2, 2010, pp. 784-792.
  4.  X. Ren, C. Y. Lai, V. Venkataramanan, F. L. Lewis, S. S. Ge and T. Liew, “Feedforward Control Based on Neural Networks for Disturbance Rejection in Hard Disk Drives,” IET Control Theory and Applications, Vol. 3, Issue 4, 2009, pp. 411-418.

Conference Proceedings

  1. T. Y. Wu and C. Y. Lai, “An Adaptive Neural Network Compensator for Decoupling of Dynamic Effect in a Macro-Mini Manipulator,” accepted for presentation at the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, July 2015, Busan, Korea.
  2. J. S. Short, A. N. Poo, M. H. Ang, C. Y. Lai, and P. Y. Tao, “A Generalized Underactuated Robot System Inversion Method using Hamiltonian Formalism,” accepted for presentation at the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, July 2015, Busan, Korea.
  3. C. Y. Lai, “Improving Transient Performance in Robotics Force Control using Nonlinear Damping,” in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Besancon, France, July 2014, pp. 892-897.
  4. C. Y. Lai, “Decoupling of Macro-Mini Manipulator using Adaptive Neural Networks,” in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Besancon, France, July 2014, pp. 898-903.
  5. J. S. Short, A. N. Poo, M. H. Ang, C. Y. Lai and P. Y. Tao, “Hamiltonian Exploitation in Underactuated Robot System Inversion”, in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Besancon, France, July 2014, pp. 904-909.
  6. A. S. Arifin, M. H. Ang, C. Y. Lai, and C. W. Lim, “General Framework of the Force and Compliant Motion Control for Macro Mini Manipulator,” in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Wollongong, Australia, Jul 2013, pp. 949-954.
  7. A. S. Arifin, M. H. Ang, C. W. Lim, and C. Y. Lai, “Improving Positioning Accuracy using a General Framework for Macro Mini Manipulation,” in Proceedings of the IFAC Symposium on Mechatronic Systems, Hangzhou, China, Apr 2013, pp. 225-230.
  8. C. Y. Lai, Y. P. Li, N. D. Vuong, T. M. Lim, C. Y. Ma, and C. W. Lim, “Nonlinear Damping for Improved Transient Performance in Robotics Force Control,” in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Kaohsiung, Taiwan, Jul. 2012, pp. 314-319.
  9. P. Y. Tao, G. Yang, Y. C. Sun, M. Tomizuka, and C. Y. Lai, “Product-of-Exponential (POE) Model for Kinematic Calibration of Robots with Joint Compliance,” in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Kaohsiung, Taiwan, Jul. 2012, pp. 496-501.
  10.  C. Y. Lai, C. Xiang, and T. H. Lee, “Identification and Control of Nonlinear Systems using Piecewise Affine Models,” in Proceedings of the 11th International Conference on Control, Automation, Robotics and Vision, Singapore, December 2010, pp. 2259-2265.
  11.  C. Y. Lai, C. Xiang, and T. H. Lee, “Identification and Control of Nonlinear Systems via Piecewise Affine Approximation,” in Proceedings of the IEEE Conference on Decision and Control, Atlanta, USA, December 2010, pp. 6395-6402.
  12.  C. Y. Lai, C. Xiang, and T. H. Lee, “Identification and Control of Piecewise Affine Systems using Multiple Models and Model Predictive Control,” in Proceedings of the 12th IASTED International Conference on Control and Applications 2010, Banff, Canada, July 2010, pp. 530-537.
  13. C. Y. Lai, C. Xiang, and T. H. Lee, “Identification of Piecewise Affine Systems and Nonlinear Systems using Multiple Models,” in Proceedings of the IEEE International Conference on Control and Automation 2010, Xiamen, China, June 2010, pp. 2005-2012.
  14. C. Y. Lai, C. Xiang, and T. H. Lee, “Identification of Linear Time-Varying System using Multiple Models,” in Proceedings of the IASTED International Conference on Modelling, Simulation and Identification (Robotics, Telematics and Applications), Beijing, China, Oct. 2009, paper 661-028.
  15. C. Xiang, C. Y. Lai, T. H. Lee, and K. S. Narendra , “A General Framework for Least-Squares Based Identification of Time-Varying System using Multiple Models,” in Proceedings of the IEEE International Conference on Control and Automation 2009, Christchurch, New Zealand, Dec. 2009, pp. 212-219.
  16. C. Y. Lai, C. Xiang, and T. H. Lee “Input-output Transition Models for Discrete-time Switched Nonlinear Systems,” in Proceedings of the 2009 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Singapore, July 2009, pp. 112-117.
  17. C. Y. Lai, F. L. Lewis, V. Venkataramanan, X. Ren, S. S. Ge and T. Liew, “Neural Networks for Disturbance and Friction Compensation in Hard Disk Drives“, in Proceedings of the 47th IEEE Conference on Decision and Control, Cancun, Mexico, 2008, pp. 3640-3645.
2011

CHEN Zhen Cheng, Clarice, PhD

Thesis Title: Towards Topical Antifibrotics in Tissue Engineering and Repair

2010

CHEN Zhi Xiong, PhD

Thesis Title: Role of Bcl-2 in metabolic and redox regulation via its effects on cytochrome c oxidase and mitochondrial functions in tumor cells

Selected Peer-reviewed Publications

  1. Cai, W.*, Chen, Z.X.*, Rane, G., Singh, S.S., Choo, Z., Wang, C., Yuan, Y., Tan, T.Z., Arfuso, F., Yap, C.T., Pongo, L.S., Yang, H., Lee, M.B., Goh, B.C., Sethi, G., Benoukraf, T., Tergaonkar, V., Kumar, A.P. Wanted DEAD/H or Alive: Helicases Winding Up in Cancers. J Natl Cancer Inst (2017) 109 (6): djw278. doi: https://doi.org/10.1093/jnci/djw278
  2. Choo, Z., Koh, R.Y., Wallis, K., Koh, T.J., Kuick, C.H., Sobrado, V., Kenchappa, R.S., Loh, A.H., Soh, S.Y., Schlisio, S., Chang, K.T. and Chen, Z.X. XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis. Oncotarget. 7(23):34229-39, 7 Jun 2016
  3. Li, S., Fell, S.M., Surova, O., Smedler, E., Wallis, K., Chen, Z.X., Hellman, U., Johnsen, J.I., Martinsson, T., Kenchappa, R.S., Uhlén, P., Kogner, P., and Schlisio, S. The 1p36 tumor suppressor KIF1Bβ is required for Calcineurin activation controlling mitochondrial fission and apoptosis.  Developmental Cell, Volume 36, Issue 2, p164–178, 25 January 2016 
  4. Chen, Z.X., Wallis, K., Fell, S.M., Sobrado, V.R., Hemmer, M.C., Ramsköld, D., Hellman, U., Sandberg, R., Kenchappa, R., Martinsson, T., Johnsen, J.I., Kogner, P. and Schlisio, S. RNA helicase A is a downstream mediator of KIF1Bβ tumor suppressor function in neuroblastoma. Cancer Discov. 4(4):434-51, 20 Mar 2014*
    *Bernards, R. Unlikely suspects identified in neuroblastoma conspiracy. Cancer Discov. 4(4):392-3, 4 Apr 2014. (Article Highlight)
2009

LIM Shushan Linda, PhD

Thesis Title: Dual Roles of Transcription Factor Zic3 in Regulating Embryonic Stem Cell Pluripotency and Differentiation

2008

Farhana Binte Mohmammed Anuar, PhD

Thesis Title: The role of nitric oxide and other gaseous mediators in cardiovascular disease models; emphasis on septic shock