NUS Graduate School for Integrative Sciences and Engineering

YAN Jie

Supervisor
Research Areas
Brief Description of Research
1. Physical principles of mechanosensing mechanisms of biomolecules.
2. DNA packaging and gene regulations.
3. DNA damage repair proteins.

 

1. DNA structures, functions, and transitions
2. Mechanics and interactions of focal adhesion and cell-cell junction proteins
3. Mechanisms of the bacterial H-NS mediated gene-silencing and regulations
4. Regulation of DNA damage repairing RecA and Rad51 nucleoprotein filaments
5. Development of high throughput single-molecule force spectroscopy and imaging techniques