To understand how genes are
compacted in cells, bacterial, and viruses.
2.
How genes are transcribed and
regulated.
3.
How viruses are replicated in host cells.
4.
How to detect specific interactions between
DNA and important proteins or enzymes.
Our research is based on highly sensitive single-molecule
manipulation and imaging techniques. It also requires
understanding mechanics of biopolymers.
1.
Mechanical properties of anomalous short DNA
molecules.
2.
Effect of Integration Host Factor (IHF).
3.
Biophysical approaches to studying in-vivo
chromatins.
4.
Single-DNA study of DNA organized in cells.
5.
Single-molecule study of dengue virus
helicase NS3 on DNA and RNA templates.
6.
Single-molecule study of SsrB-HN/s protein
interactions.
Research Area(s)
1.
DNA organization in cells, batcerial, and viruses; DNA-protein interactions
2.
Micromechanics of biopolymers and polymer physics; folding and unfolding of biopolymers
3.
Gene transcription and regulation dynamics
4.
Virus replication mechanism in host cells
5.
Development of novel single-molecule manipulation techniques
