NUS Graduate School for Integrative Sciences and Engineering

TAN Yee Joo

Supervisor
Research Areas
Brief Description of Research
1. Infectious Diseases

 

After infecting their hosts, viruses encounter the formidable task of having to multiply in the face of a vigorous host response. Importantly, the interaction between virus and host will determine the outcome of the viral infection. The aim of my laboratory is to understand how viruses can infect and subsequently employ the host cell machineries for their own benefit to cause severe. Currently, we are studying novel viral-host interaction implicated in the replication of newly emerged viruses, such as the Middle East Respiratory Syndrome coronavirus and avian influenza A virus. In addition, our laboratory also research on Hepatitis B and C viruses, the two major players which cause chronic liver diseases worldwide.

The host’s ability to mount a robust immune response during viral infection is critical for recovery. However, this is sometimes not achieved and the virus gains the opportunity to invade, make use of and harm the host. Thus, our laboratory also focuses on understanding the humoral response against highly pathogenic viruses and identifying potential therapeutic monoclonal antibodies that are targeting different viral proteins. By mapping the binding epitopes of these monoclonal antibodies and the mechanism by which virus escapes antibody neutralisation, we aim to determine how they can be harnessed as powerful tools for fighting severe viral infection.