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The critical role of lipids is
demonstrated by a large number of genetic studies and by
many human diseases involving the disruption of lipid
metabolic enzymes and pathways. Examples of such diseases
include cancer, diabetes, neurodegenerative and infectious
disorders. Novel analytical approaches now allow for "lipidomics":
systems level analysis of lipids and their interacting
partners.
We recently started a new program termed "Lipidomics, novel
tools and applications", which is built on basic research
and engineering with a strong outlook on applications,
merging facets of medicine, cell/biology, bio/engineering,
organic chemistry and bioinformatics. It will enhance
international connections with new initiatives such as the
SMART center for Infectious Diseases, SystemsX.ch (ETH
Zurich) and the Cellular Neuroscience, Neurodegeneration and
Repair (CNNR) program at Yale University. Our industrial
partners include The Novartis Institute for Tropical
Diseases as well as analytical instrument manufacturer
Applied Biosystems in co-development and application of the
above tools.
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